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Medisafe Launches Feature to Alert Users of Potentially Harmful Drug Interactions
Platform to differentiate notifications based on risk category, from 'minor' to 'severe'

ORLANDO, Fla., Feb. 21, 2017 /PRNewswire/ -- HIMSS 2017 Annual Conference & Exhibition -- Medisafe®, the leading personalized medication management platform with three and a half million patient and caregiver registered users, today announced a new feature to alert users of possible drug-to-drug interactions that may cause unexpected side effects and/or alter the way the medications perform. The interactions feature also includes disclosures when medications have other lifestyle implications, such as interactions with specific foods or alcohol.

With this latest enhancement, Medisafe is aiming to reduce the millions of preventable health emergencies resulting from dangerous medication combinationsi as well as to increase adherence to medications patients are not taking as prescribed, due to side effects related to a known interaction. The majority of Medisafe users are managing multiple medications; in many cases the medications are filled at different pharmacies and downloaded directly into Medisafe using the app's medication import feature. As a result, an individual physician may not know all of the drugs a patient has been prescribed.

Annually, medication errors lead to an estimated 44,000 to 98,000 deaths. Of this total, an estimated 7,000 deaths occur due to adverse drug reactions.ii Less understood to date is the impact on adherence. However, a recent study conducted by Medisafe found adherence to some common medications to be as much as 10% lower when taken with a contraindicated medication. The study also found that, on average, two out of 10 Medisafe users taking at least two medications are at risk of a "major" or "severe" interaction.

The Medisafe platform distinguishes between interactions based on their level of health risk using a four-point scale ("minor," "moderate," "major" and "severe"), taking a triaged approach to its communications accordingly.

  • After Medisafe users add a medication that has a known "severe" or "major" interaction with another medication in their virtual pillbox, they receive an alert in the app's Updates section (a.k.a the "feed") advising them of the potential dangers and to consult their treating physician immediately.
  • All interactions, from "minor" and "severe," as well as lifestyle, appear on a drug's "med info" screen. Users can consult this screen at any time, but they will not receive a proactive alert.
  • In the coming weeks, users will be able to look up the known interactions for any medication using Medisafe's soon-to-be-launched "Interaction Checker."

In a recent study of 225 U.S. drug stores, over 50% of tested pharmacies dispensed dangerous drug pairs without warning patients of risks, revealing an industry-wide trend of misinformed patients.iii With as many as one in five Americans taking three or more medications, and one in ten taking five or more, dangerous drug combinations pose a major threat to patients throughout all disease classes.iv Common adverse lifestyle interactions include: caffeine and certain asthma medications, grapefruit juice and various high cholesterol medications, alcohol and various narcotics, and more.v  

"Dangerous drug-to-drug interactions are preventing people trying to follow their prescribed regimens from getting the expected benefit, sending them to the hospital unnecessarily, or even causing premature deaths," stated Jon Michaeli, executive vice president of business development and marketing at Medisafe. "What is truly exciting is that our platform has all the requisite data, so we are in a unique position to catch these interactions early on, keeping patients out of harm's way and continuing their path to better health. And in many cases, we will help close the loop with doctors and care managers in their constant effort to maintain accurate medication records for their patients."

"Anytime a patient takes more than one medication, or mixes it with certain foods, beverages, or over-the-counter medicines, they are at risk of a drug interaction," stated Dr. Daniel Mosby of the Sheffield Teaching Hospitals NHS Foundation Trust. "With this feature, Medisafe will alert users of any known interactions, and information on when to talk with their healthcare provider, providing an extra layer of protection and peace of mind that their medications are working effectively and as prescribed." 

"When patients get prescriptions at different pharmacies from various specialists, it's nearly impossible for one doctor or pharmacy to know what the other has given to them," stated Barbara Zink-Frederick, CRNP. "What patients need to understand is how these different prescriptions interact and how to talk with their doctors about any possible adverse events. This platform is providing the necessary tools for this type of proactive and holistic medication management."

Medisafe's new drug interaction feature is initially available for iOS users.

For more information about Medisafe, please visit  

About Medisafe
Medisafe is the personalized medication management platform addressing all major causes of non-adherence. Medisafe's cloud-based mobile platform personalizes content, resources and interventions — such as educational videos, coupons and motivational messages — based on each user's regimen, condition and specific circumstance. Medisafe fosters collaboration between patients, their loved ones and healthcare professionals through caregiver tools and reports, and helps the care continuum improve health outcomes and sustain quality care initiatives. Medisafe's three and a half million patient and caregiver users who have recorded over 500 million successful medication doses on their iOS and Android smartphones and tablets and contributed 140,000 user reviews that average 4.5 out of 5 stars in the App Store and Google Play app stores.

Lindsey Diaz-MacInnis
Racepoint Global
(617) 624-3484

i Strandell, J., Bate, A., Lindquist, M., & Edwards, I. R. (2008). Drug–drug interactions – a preventable patient safety issue? British Journal of Clinical Pharmacology, 65(1), 144–146. Retrieved from:
ii Committee on Quality of Health Care in America: Institute of Medicine. To err is human: building a safer health system. Washington, D.C.: National Academy Press; 2000. Retrieved from: of Drug Interactions
iii The Chicago Tribune: Pharmacies miss half of dangerous drug combinations Sam Roe-Ray Long-Karisa King. Retrieved from:
iv Therapeutic Drug Use. Retrieved from:
v Avoid Food-Drug Interactions. (n.d.). Retrieved from

SOURCE Medisafe